Emedastina [INN-Spanish]
Brand names,
Emedastina [INN-Spanish]
Analogs
Emedastina [INN-Spanish]
Brand Names Mixture
Emedastina [INN-Spanish]
Chemical_Formula
C22H23N3O4
Emedastina [INN-Spanish]
RX_link
http://www.rxlist.com/cgi/generic4/tarceva.htm
Emedastina [INN-Spanish]
fda sheet
Emedastina [INN-Spanish]
msds (material safety sheet)
Emedastina [INN-Spanish]
Synthesis Reference
No information avaliable
Emedastina [INN-Spanish]
Molecular Weight
393.436 g/mol
Emedastina [INN-Spanish]
Melting Point
No information avaliable
Emedastina [INN-Spanish]
H2O Solubility
Very slightly soluble (hydrochloride salt - maximal solubility of approximately 0.4 mg/mL occurs at a pH of approximately 2)
Emedastina [INN-Spanish]
State
Solid
Emedastina [INN-Spanish]
LogP
3.126
Emedastina [INN-Spanish]
Dosage Forms
Tablet (27.3 mg, 109.3 mg or 163.9 mg)
Emedastina [INN-Spanish]
Indication
For the treatment of patients with locally advanced or metastatic non-small cell lung cancer after failure of at least one prior chemotherapy regimen. Also for use, in combination with gemcitabine, as the first-line treatment of patients with locally advanced, unresectable or metastatic pancreatic cancer.
Emedastina [INN-Spanish]
Pharmacology
Erlotinib is a Human Epidermal Growth Factor Receptor Type 1/Epidermal Growth Factor Receptor (HER1/EGFR) tyrosine kinase inhibitor.
Emedastina [INN-Spanish]
Absorption
Erlotinib is about 60% absorbed after oral administration and its bioavailability is substantially increased by food to almost 100%.
Emedastina [INN-Spanish]
side effects and Toxicity
Symptoms of overdose include diarrhea, rash, and liver transaminase elevation.
Emedastina [INN-Spanish]
Patient Information
Emedastina [INN-Spanish]
Organisms Affected
Humans and other mammals